EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS

EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS

ABSTRACT

Starch is a major carbohydrate, easily extractable from various sources like cassava, maize, potato etc which find wide application in various food and Pharmaceutical industries. There has been a lot of attempt to modify this highly flexible polymer with the aim of extending and enhancing its applications. Native cassava starch (NCS) was extracted from the tubers of freshly harvested cassava. Enzyme- hydrolysed starch (EHS) was produced from Native cassava starch (NCS) using enzymatic hydrolysis method with α – amylase as the enzyme. The physicochemical characterization for NCS and EHS was conducted using standard methods, such as flow rate, angle of repose, mean particle size, moisture content, Carr‟s index, Hausner‟s ratio, ash content, swelling power, pH, bulk and tapped densities. Chloroquine tablets were formulated by wet granulation method and direct compression using EHS, MCC, MS and NCS as binders at different concentrations of 2.5, 5, 7.5 and 10 %w/v. The tablet characteristics were evaluated and compared with that of MCC and maize starch. The mechanical properties using crushing strength and friability for NCS and EHS were carried out. The crushing strength increased with increase in binder concentration while friability decreased. The disintegration time also increased with increase in binder concentration. The disintegration and dissolution profile of the tablets were studied and these were much faster for EHS tablets when compared to that of PVP. Using the direct compression method, crushing strength was found to increase with increase in binary mixture of MCC and the friability increases with increase in the viii proportion of EHS. The Disintegration time was above 60 min., the tablet continued to swell, absorbing more water without disintegrating for the period of the study. The study found out that EHS is comparable to standard starches and can be used as a binder in wet granulation and direct compression method in Pharmaceutical industries to produce the tablets.

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